Phosphorylation of C/EBP Inhibits Granulopoiesis
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منابع مشابه
miRNA-130a regulates C/EBP-ε expression during granulopoiesis.
CCAAT/enhancer binding protein-ε (C/EBP-ε) is considered a master transcription factor regulating terminal neutrophil maturation. It is essential for expression of secondary granule proteins, but it also regulates proliferation, cell cycle, and maturation during granulopoiesis. Cebpe(-/-) mice have incomplete granulocytic differentiation and increased sensitivity toward bacterial infections. Th...
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apoptosis. As the authors note, the phenotypic features of C/EBP -deficient granulopoiesis resemble those of a myelodysplastic syndrome. Because C/EBP mutations and/or dysfunction are known to be involved in the pathogenesis of acute myeloid leukemia (AML), it is possible that inactivation of other C/EBP proteins such as C/EBP play a role in myeloid disorders (MDSs) as well. For example, C/EBP ...
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The transcription factor C/EBP alpha (CCAAT/enhancer binding protein alpha) is critical for granulopoiesis. Gene disruption in mice blocks early granulocyte differentiation and disruption of C/EBP alpha function has been implicated in human acute myeloid leukemia (AML), but no systematic structure-function analysis has been undertaken to identify the mechanisms involved in C/EBP alpha-mediated ...
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Mammalian neurogenesis is determined by an interplay between intrinsic genetic mechanisms and extrinsic cues such as growth factors. Here we have defined a signaling cascade, a MEK-C/EBP pathway, that is essential for cortical progenitor cells to become postmitotic neurons. Inhibition of MEK or of the C/EBP family of transcription factors inhibits neurogenesis while expression of a C/EBPbeta mu...
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